CCND1 antibody (10R-1737)

Mouse monoclonal CCND1 antibody

Synonyms Monoclonal CCND1 antibody, Anti-CCND1 antibody, U21B31 antibody, Cyclin D1 antibody, CCND 1 antibody, PRAD1 antibody, BCL1 antibody, CCND 1, CCND-1, CCND-1 antibody, D11S287E antibody, CCND1
Specificity Human CCND1
Cross Reactivity Human. Other species not studied
Applications Dot Blot
Immunogen CCND1 antibody was raised in mouse using recombinant Human Cyclin D1 (Ccnd1)

Images

Western blot analysis using CCND1 antibody (10R-1737)

Specifications

Host Mouse
Clone 2118C2a
Isotype IgG1
Method of Purification CCND1 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer CCND1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

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Images

  • Western blot analysis using CCND1 antibody (10R-1737) |

Availability: In stock

Price: $190.00
Size: 50 ug
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