CCND1 antibody (70R-10480)

Affinity purified rabbit polyclonal CCND1 antibody

Synonyms Polyclonal CCND1 antibody, Anti-CCND1 antibody, cyclin D1 antibody, U21B31 antibody, CCND-1 antibody, D11S287E antibody, BCL1 antibody, PRAD1 antibody, CCND1, CCND 1, CCND 1 antibody, CCND-1
Cross Reactivity Human, Mouse, Rat, Dog, Bovine, Zebrafish, African Clawed Frog, Chicken
Applications WB
Immunogen CCND1 antibody was raised in rabbit using the middle region of CCND1 as the immunogen
Assay Information CCND1 Blocking Peptide, catalog no. 33R-1076, is also available for use as a blocking control in assays to test for specificity of this CCND1 antibody

Images

Western blot analysis using CCND1 antibody (70R-10480)

Recommended CCND1 Antibody Titration: 0.2-1 ug/ml

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-1 ug/ml

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

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Images

  • Western blot analysis using CCND1 antibody (70R-10480) | Recommended CCND1 Antibody Titration: 0.2-1 ug/ml

Availability: In stock

Price: $345.00
Size: 50 ug
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