CCNH antibody (10R-1648)

Mouse monoclonal CCNH antibody

Synonyms Monoclonal CCNH antibody, Anti-CCNH antibody, p34 antibody, CAK antibody, Cyclin H antibody, p37 antibody
Specificity Human CCNH
Cross Reactivity Human. Other species not studied
Applications Dot Blot
Immunogen CCNH antibody was raised in mouse using recombinant Human Cyclin H (Ccnh)

Images

Western Blot analysis of immunized recombinant protein using CCNH antibody (10R-1648)

Left: CCNH staining. Right: Coomassie Blue staining of immunized recombinant protein.

Specifications

Host Mouse
Clone 2125C2a
Isotype IgG2a
Method of Purification CCNH antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer CCNH antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery.

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Images

  • Western Blot analysis of immunized recombinant protein using CCNH antibody (10R-1648) | Left: CCNH staining. Right: Coomassie Blue staining of immunized recombinant protein.

Availability: In stock

Price: $190.00
Size: 50 ug
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