CD20 antibody (10R-8136)

Mouse monoclonal CD20 antibody

Synonyms Monoclonal CD20 antibody, Anti-CD20 antibody, CD 20 antibody, CD-20 antibody, CD 20, CD-20, CD20
Cross Reactivity Human
Applications ELISA, FC, IHC-F, IP
Immunogen CD20 antibody was raised in Mouse using Daudi cells (Burkitt lymphoma) as the immunogen.

Specifications

Host Mouse
Clone NKI-B20
Isotype IgG1, IgG2a, IgG2b
Form & Buffer Supplied in PBS containing 0.09% sodium azide

Usage & Assay Information

Usage Recommendations Optimal dilution should be determined by titration

General Information

Biological Significance The antigen recognized by CD20 MAbs is a 35-37 kDa non-glycosylated phosphoprotein, that may function as a Ca2+ ion channel The protein structure deduced from cloned DNA sequence suggests that the CD20 antigen is a transmembrane protein that passes the membrane four times, with both the C- and the N-terminus on the cytoplasmic side and only a small part exposed on the cell surface. Expression of CD20 antigen is specific for B lymphocytes and is present during most differentiation stages, beginning at the early pre-B cell stage and disappearing upon differentiation into plasma cells. The CD20 molecule appears to be involved in the activation and cell cycle progress of B lymphocytes. Stimulating as well as inhibitory effects in different phases of the cell cycle have been reported for different CD20 MAbs.

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Availability: In stock

Price: $395.00
Size: 100 ug
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