CD59 protein (His tag) (80R-2964)
Purified recombinant APOL4 protein (His tag)
|Synonyms||CD59 glycoprotein protein, 16.3A5 protein, 1F5 protein, EJ16 protein, EJ30 protein, EL32 protein, G344 protein, HRF-20 protein, HRF20 protein, MAC-IP protein, MACIF protein, MEM43 protein, MIC11 protein, MIN1 protein, MIN2 protein, MIN3 protein, MIRL protein, MSK21 protein, p18-20 protein|
SDS-PAGE analysis of CD59 protein (His Tag) (80R-2964)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||26-102 aa: MGSSHHHHHH SSGLVPRGSH MGSLQCYNCP NPTADCKTAV NCSSDFDACL ITKAGLQVYN KCWKFEHCNF NDVTTRLREN ELTYYCCKKD LCNFNEQLEN|
|Purity||> 85% pure|
|Molecular Weight||11.3 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT|
Storage & Safety
|Storage||Store at 4 deg C for up to 2 weeks. For long term storage, aliquot and store at -20 deg C to -70 deg C. Avoid repeated freeze/thaw cycles|
|Biological Significance||CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. It also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction.|
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