CD74 antibody (10R-CD74aHU)

Mouse monoclonal CD74 antibody

Synonyms Monoclonal CD74 antibody, Anti-CD74 antibody, CD 74, CD74, CD 74 antibody, CD-74, CD-74 antibody
Specificity Human
Cross Reactivity To be determined by end-user
Applications FC
Immunogen CD74 antibody was raised in mouse using RPMI 1788 Cell line as the immunogen.

Specifications

Host Mouse
Clone M-B741
Isotype IgG2a
Purity > 95% pure
Method of Purification CD74 antibody was purified by Protein A chromatography.
Form & Buffer 50mM Na3PO4, pH 7.5, with 100mM KCL, 150mM NaCl, and 0.5 mg/ml gentamycin sulfate.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations FC: 5 ug/ml

Storage & Safety

Storage Store at 4 deg C.

General Information

Biological Significance Human CD74 is expressed intracellularly and on the cell surface of MHC Class II positive cells such as B cells, monocytes, macrophages, Langerhans cells and dendritic cells. CD74 has several important functions relating to antigen presentation by MHC Class II molecules.

References
Add a Paper

Jiaqiang Caia, Mark Baugha, Darcey Blacka, Clive Longa, D. Jonathan Bennetta, Maureen Dempstera, Xavier Fraderaa, Jonathan Gillespiea, Fiona Andrewsa, Sylviane Boucharensa, John Bruina, Kenneth S. Camerona, Iain Cumminga, William Hamiltona, Philip S. Jonesa, Allard Kapteinb, Emma Kinghorna, Maurice Maidmenta, Iain Martina, Ann Mitchella, Zoran Rankovica, John Robinsona, Paul Sculliona, Joost C.M. Uitdehaagb, Paul Vinkb, Paul Westwooda, Mario van Zeelandb, Leon van Berkomc, Martijn Bastianic, Tommi Meulemansc

6-Phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile as cathepsin S inhibitors

Bioorganic & Medicinal Chemistry Letters

Volume: 20 Issue: 15 Page: 4350-4354 DOI: 10.1016/j.bmcl.2010.06.072

Mark Baugha, Darcey Blacka, Paul Westwooda, Emma Kinghorna, Kieran McGregora, John Bruina, William Hamiltona, Maureen Dempstera, Christopher Claxtona, Jiaqiang Caia, Jonathan Bennetta, Clive Longa, Heather Mckinnona, Paul Vinkb, Leontien den Hoedb, Monika Goreckab, Kalpit Vorac, Ethan Grantc, M. David Percivald, A. Mieke H. Bootsb, Marie-José van Lierop

Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity

Journal of Autoimmunity

Volume: 36 Issue: 3-5 Page: 201-209 DOI: 10.1016/j.jaut.2011.01.003

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Availability: In stock

Price: $346.50
Size: 100 ug
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