CDK6 antibody (10R-8438)

Mouse monoclonal CDK6 antibody

Synonyms Monoclonal CDK6 antibody, Anti-CDK6 antibody, CDK6 antibody, cyclin-dependent kinase 6 antibody, 5830411I20 antibody, BOS_4031 antibody, cell division protein kinase 6 antibody, CH211-234F14.1 antibody, CR2 protein kinase antibody, Crk2 antibody, EGK_13940 antibody, plstire antibody, serine/threonine-protein kinase PLSTIRE antibody
Cross Reactivity Human
Applications ELISA, WB
Immunogen CDK6 antibody was raised in Mouse using a recombinant human protein purified from E.coli as the immunogen

Images

Western Blot analysis using CDK6 antibody (10R-8438)

Specifications

Host Mouse
Clone 75B9
Isotype IgG2b kappa
Method of Purification CDK6 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:500

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Cyclin-dependent kinase 6 (CDK6) is a 40 kDa member of the CDK family of mitotic kinases involved in cell cycle progression. CDKs are the catalytic subunits of the cyclin/CDK complexes, which phosphorylate substrates on threonine/serine residues. CDK6 associates with the D-type cyclins and is important in the progression of cells from the G1-phase to the S-phase of the cell cycle. Loss of normal cell cycle regulation is the hallmark of human cancers, and alteration of the components involved in cell cycle regulation occurs in most human tumors. This suggests that CDK6 is an attractive target for the development of pharmacological agents for the treatment of cancer. Recently, several studies have indicated a novel role for cdk6 in differentiation, also.

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Images

  • Western Blot analysis using CDK6 antibody (10R-8438) |

Availability: In stock

Price: $295.00
Size: 100 ul
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