CDKN1B antibody (70R-10482)
Affinity purified rabbit polyclonal CDKN1B antibody
|Synonyms||Polyclonal CDKN1B antibody, Anti-CDKN1B antibody, MEN1B antibody, KIP1 antibody, CDKN1B, cyclin-dependent kinase inhibitor 1B, Kip1 antibody, CDKNB-1, p27, CDKNB-1 antibody, CDKN4 antibody, CDKNB 1, MEN4 antibody, P27KIP1 antibody, CDKNB 1 antibody|
|Immunogen||CDKN1B antibody was raised in rabbit using the C terminal of CDKN1B as the immunogen|
|Assay Information||CDKN1B Blocking Peptide, catalog no. 33R-2658, is also available for use as a blocking control in assays to test for specificity of this CDKN1B antibody|
Western Blot analysis using CDKN1B antibody (70R-10482)
CDKN1B antibody (70R-10482) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||CDKN1B is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. It binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.|
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