CDKN2C antibody (10R-1585)

Mouse monoclonal CDKN2C antibody

Synonyms Monoclonal CDKN2C antibody, Anti-CDKN2C antibody, CDKNC-2 antibody, Cyclin-dependent kinase inhibitor 2C antibody, p18-INK4C antibody, CDKN2C, CDKNC 2 antibody, p18 antibody, INK4C antibody, CDKNC 2, CDKNC-2
Specificity Human CDKN2C
Cross Reactivity Human. Other species not studied
Applications Dot Blot, ICC
Immunogen CDKN2C antibody was raised in mouse using recombinant Human Cyclin-Dependent Kinase Inhibitor 2C (P18, Inhibits Cdk4) (Cdkn2C)

Images

Immunofluorescent staining using CDKN2C antibody (10R-1585)

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-CDKN2C antibody.

Specifications

Host Mouse
Clone 2148C1a
Isotype IgG1
Method of Purification CDKN2C antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer CDKN2C antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations ICC: 2-100 ug/ml

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance The protein encoded by this gene is a member of the INK4 family of cyclindependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

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Images

  • Immunofluorescent staining using CDKN2C antibody (10R-1585) | Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-CDKN2C antibody.
  • Western Blot analysis of immunized recombinant protein using CDKN2C antibody (10R-1585)

Availability: In stock

Price: $190.00
Size: 50 ug
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