CFLAR antibody (70R-10445)
Affinity purified rabbit polyclonal CFLAR antibody
|Synonyms||Polyclonal CFLAR antibody, Anti-CFLAR antibody, I-FLICE antibody, c-FLIP antibody, Casper antibody, CASP8 and FADD-like apoptosis regulator antibody, c-FLIPS antibody, CASP8AP1 antibody, FLIP antibody, USURPIN antibody, FLAME antibody, c-FLIPL antibody, CLARP antibody, FLAME-1 antibody, MRIT antibody, c-FLIPR antibody, CASH antibody|
|Immunogen||CFLAR antibody was raised in rabbit using the middle region of CFLAR as the immunogen|
|Assay Information||CFLAR Blocking Peptide, catalog no. 33R-5234, is also available for use as a blocking control in assays to test for specificity of this CFLAR antibody|
Western Blot analysis using CFLAR antibody (70R-10445)
Western Blot showing CFLAR antibody used at a concentration of 1-2 ug/ml to detect its target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||CFLAR belongs to the peptidase C14A family. It is a apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. The protein acts as an inhibitor of TNFRSF6 mediated apoptosis. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. CFLAR lacks enzymatic (caspase) activity.|
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