CFLAR protein (30R-2082)

Recombinant human CFLAR protein

Synonyms c-FLIP protein, USURPIN protein, I-FLICE protein, FLIP protein, CLARP protein, MRIT protein, FLAME protein, Casper protein, FLAME1 protein, FLAME-1 protein, CASP8 and FADD-like apoptosis regulator protein, CASH protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of CFLAR protein (30R-2082)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 1-480 amino acids: MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY VVSEGQLENS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT
Expression System E.coli
Purity > 85% pure
Molecular Weight 55.3 kDa (480aa)
Form & Buffer Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations CFLAR protein has been used in SDS PAGE, and may be suitable for use in other assays, to be determined by the end user.

Storage & Safety

Storage Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.

General Information

Biological Significance CFLAR, also known as FLIP, is involved in the regulation of apoptosis. It has been designated by independent groups as Casper, I-FLICE, CLARP, FLAME-1 and MRIT. Although its exact role is still being elucidated, it appears to be an important factor in the regulation of apoptosis downstream of all known death receptors. Recombinant human CFLAR protein was expressed in E.coli and denatured using detergent during a conventional chromatography purification process.

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Images

  • Coomassie Blue stained SDS-PAGE of CFLAR protein (30R-2082) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: $295.00
Size: 100 ug
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