CHIT1 antibody (10R-2159)
Mouse monoclonal CHIT1 antibody
|Synonyms||Monoclonal CHIT1 antibody, Anti-CHIT1 antibody, CHIT1, CHIT 1, CHIT 1 antibody, CHIT-1, CHIT antibody, CHIT-1 antibody, Chitotriosidase antibody, Chitinase 1 antibody|
|Immunogen||CHIT1 antibody was raised in Mouse using a purified recombinant fragment of CHIT1(aa22-137) expressed in E. coli as the immunogen.|
Western Blot analysis using CHIT1 antibody (10R-2159)
Western Blot showing CHIT1 antibody used against truncated Trx-CHIT1 recombinant protein (1) and truncated CHIT1 (aa22-466)-hIgGFc transfected CHO-K1 cell lysate (2).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CHIT1 is a 50 kDa secreted glycoprotein that belongs to glycohydrolase family # 18. It is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.|
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