CHMP1B protein (His tag) (80R-2311)
Purified recombinant Human CHMP1B Protein (His tag)
|Synonyms||CHMPB-1 protein, CHMPB 1 protein, Vps46B protein, Vps46-2 protein, C10orf2 protein, hVps46-2 protein, CHMPB-1, CHMP1B, CHMPB 1, CHMP1.5 protein, C18-ORF2 protein, C18orf2 protein|
Coomassie Blue stained SDS-PAGE of CHMP1B protein (His tag) (80R-2311)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MGSSHHHHHH SSGLVPRGSH MGSHMSNMEK HLFNLKFAAK ELSRSAKKCD KEEKAEKAKI KKAIQKGNME VARIHAENAI RQKNQAVNFL RMSARVDAVA ARVQTAVTMG KVTKSMAGVV KSMDATLKTM NLEKISALMD KFEHQFETLD VQTQQMEDTM SSTTTLTTPQ NQVDMLLQEM ADEAGLDLNM ELPQGQTGSV GTSVASAEQD ELSQRLARLR DQV|
|Purity||> 85% pure|
|Molecular Weight||24.7 kDa|
|Form & Buffer||Supplied in liquid form in 20 mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||CHMP1B, also known as charged multivesicular body protein 1b, is probable peripherally associated component of the endosomal sorting required for transport complex III which is involved in multivesicular bodies formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Recombinant human CHMP1B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.|
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