CHRNA4 antibody (70R-10538)
Affinity purified rabbit polyclonal CHRNA4 antibody
|Synonyms||Polyclonal CHRNA4 antibody, Anti-CHRNA4 antibody, CHRNA 4 antibody, CHRNA-4, NACRA4 antibody, EBN1 antibody, EBN antibody, BFNC antibody, CHRNA4, cholinergic receptor, CHRNA-4 antibody, CHRNA 4, nicotinic, alpha 4 antibody|
|Cross Reactivity||Human, Mouse, Rat, Bovine, Chicken|
|Immunogen||CHRNA4 antibody was raised in rabbit using the N terminal of CHRNA4 as the immunogen|
|Assay Information||CHRNA4 Blocking Peptide, catalog no. 33R-2546, is also available for use as a blocking control in assays to test for specificity of this CHRNA4 antibody|
Western Blot analysis using CHRNA4 antibody (70R-10538)
Western Blot showing CHRNA4 antibody used at a concentration of 1-2 ug/ml to detect its target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.|
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