CHRNB3 antibody (70R-10542)
Affinity purified rabbit polyclonal CHRNB3 antibody
|Synonyms||Polyclonal CHRNB3 antibody, Anti-CHRNB3 antibody, CHRNB 3 antibody, cholinergic receptor, beta 3 antibody, CHRNB 3, CHRNB-3, nicotinic, CHRNB3, CHRNB-3 antibody|
|Cross Reactivity||Human, Mouse, Rat, Dog, Chicken, African Clawed Frog|
|Immunogen||CHRNB3 antibody was raised in rabbit using the middle region of CHRNB3 as the immunogen|
|Assay Information||CHRNB3 Blocking Peptide, catalog no. 33R-10069, is also available for use as a blocking control in assays to test for specificity of this CHRNB3 antibody|
Western Blot analysis using CHRNB3 antibody (70R-10542)
Western Blot showing CHRNB3 antibody used at a concentration of 1-2 ug/ml to detect its target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.03 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels nAChRs are pentameric structures that are made up of combinations of individual subunits. CHRNB3 is one of the subunits of nAChR. Twelve neuronal nAChR subunits have been described, alpha2-alpha10 and beta2-beta4. CHRNB3 decreased the channel mean open time and burst length. There was also an increase in single channel slope conductance. On the other hand, the calcium permeability and the pharmacological properties of beta3-containing receptors differed little from those of without beta3. Dysfunction of nAChR has been linked to a number of human diseases such as schizophrenia, Alzheimer's and Parkinson's diseases. nAChRs also play a significant role in nicotine addiction.|
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