CHTF18 antibody (10R-1333)

Mouse monoclonal CHTF18 antibody

Synonyms Monoclonal CHTF18 antibody, Anti-CHTF18 antibody, RUVBL antibody, C16orf41 antibody, CHTF-18, C321D2.2 antibody, CHTF 18 antibody, CHTF-18 antibody, CHL12 antibody, C321D2.4 antibody, Chromosome transmission fidelity factor 18 homolog, CHTF 18, CHTF18, C321D2.3 antibody, Ctf18 antibody
Specificity Human CHTF18
Cross Reactivity Human. Other species not studied
Applications Dot Blot, IP, WB
Immunogen CHTF18 antibody was raised in mouse using recombinant Human Ctf18, Chromosome Transmission Fidelity Factor 18 Homolog (S. Cerevisiae) (Chtf18)

Images

Western Blot analysis of immunized recombinant protein using CHTF18 antibody (10R-1333)

Specifications

Host Mouse
Clone 2182C3a
Isotype IgG1
Method of Purification CHTF18 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer CHTF18 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-2 ug/ml, IP: 100-500 ug/sample

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance CHTF18 is a chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.

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Images

  • Western Blot analysis of immunized recombinant protein using CHTF18 antibody (10R-1333)

Availability: In stock

Price: $190.00
Size: 50 ug
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