CIB1 protein (His tag) (80R-1039)
Purified recombinant Human CIB1 protein
|Synonyms||CIB protein, CIB 1, CIB1 protein, SIP2-28(SNK interacting protein2-28) protein, Calcium and integrin binding protein 1 protein, SNK interacting protein 2 to 28., CIB-1, Calcium and integrin binding 1 protein, CIB 1 protein, Human Snk interacting protein 2 to 28 mRNA complete cds protein, CIB-1 protein, Calcium and integrin binding 1 Calcium and integrin binding 1 (calmyrin) protein, CIB protein, PRKDCIP protein, KIP (Kinase interacting protein) protein, DNA PKcs interacting protein protein, CALMYRIN protein, SIP2 28 protein, Kinase interacting protein protein, CIB1|
Coomassie Blue stained SDS-PAGE of CIB1 protein (His tag) (80R-1039)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-191 amino acids: MGSSHHHHHH SSGLVPRGSH MGGSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPQ EQRTVESSLR AQVPFEQILS LPELKANPFK ERICRVFSTS PAKDSLSFED FLDLLSVFSD TATPDIKSHY AFRIFDFDDD GTLNREDLSR LVNCLTGEGE DTRLSASEMK QLIDNILEES DIDRDGTINL SEFQHVISRS PDFASSFKIV L|
|Purity||> 95% pure|
|Molecular Weight||23 kDa (211aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 5mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||CIB, KIP (Kinase interacting protein), SIP2-28 (SNK interacting protein2-28). CIB1 (Calcium and integrin binding 1) is a regulatory protein with 50% homology to calmodulin and calcineurin B, that encodes a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. Also CIB1 is widely expressed and binds to a number of effectors, such as PAK1, and polo-like kinases, in different tissues. Recombinant human CIB1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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