Cish antibody (70R-14323)

Affinity purified Rabbit polyclonal Cish antibody

Synonyms Polyclonal Cish antibody, Anti-Cish antibody, cytokine inducible SH2-containing protein antibody, Cis antibody, F17 antibody, F23 antibody, CIS1 antibody, AI385595 antibody
Applications ICC, IHC-P, WB
Immunogen Cish antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the C-terminal of human CISH, identical to the related rat and Rabbit sequences, as the immunogen

Images

Immunohistochemical staining using Cish antibody (70R-14323)

Immunohistochemistry of paraffin-embedded section of Human Lung Cancer Tissue

Specifications

Host Rabbit
Isotype IgG
Method of Purification Cish antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

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Images

  • <div><font face=Calibri size=2>Immunohistochemical staining using Cish antibody (70R-14323)</font></div>     | Immunohistochemistry of paraffin-embedded section of Human Lung Cancer Tissue
  • <div><font face=Calibri size=2>Western Blot analysis using Cish antibody (70R-14323)</font></div>     | Lane 1:Rat Liver Tissue Lysate; Lane 2:Rat Kidney Tissue Lysate; Lane 3:Human Placental Tissue Lysate; Lane 4:A431 Cell Lysate; Lane 5:SMMC Cell Lysate; Lane 6: HELA Cell Lysate; Lane 7: COLO320 Cell Lysate; Lane 8: M231 Cell Lysate

Availability: In stock

Price: $270.00
Size: 100 ug
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