CLCF1 protein (His tag) (80R-1939)

Recombinant human CLCF1 protein

Synonyms NNT1 protein, CLCF 1, BSF-3 protein, NR6 protein, CISS2 protein, CLCF 1 protein, NNT-1 protein, CLCF-1, BSF3 protein, CLCF-1 protein, CLCF1, Cardiotrophin-like cytokine factor 1 protein, CLC protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of CLCF1 protein (His tag) (80R-1939)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 28-225 amino acids: MGSSHHHHHH SSGLVPRGSH MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF
Expression System E.coli
Purity > 90% pure
Molecular Weight 24.6 kDa (219aa)
Tag/Conjugate His tag
Form & Buffer Liquid. 20mM sodium citrate (pH 3.5), 0.4M Urea, 10% glycerol
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations CLCF1 protein (His tag) has been used in SDS PAGE, and may be suitable for use in other assays, to be determined by the end user.

Storage & Safety

Storage Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.

General Information

Biological Significance CLCF1, also known as cardiotrophin-like cytokine factor 1, belongs to the interleukin 6 family of cytokines, which are involved in cell signaling through phosphorylation of gp130. CLCF1 has a sequence of 225-amino acids with a 27-aa signal peptide, a molecular mass of 22 kDa in mature form, and the highest homology to cardiotrophin-1 and ciliary neurotrophic factor. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine.

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Images

  • Coomassie Blue stained SDS-PAGE of CLCF1 protein (His tag) (80R-1939) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: $270.00
Size: 100 ug
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