CLIC1 protein (His tag) (80R-1332)
Purified recombinant Human CLIC1 protein
|Synonyms||CLIC 1 protein, CLIC-1, Nuclear chloride ion channel protein protein, Nuclear chloride ion channel 27 protein, NCC27 protein, CLIC 1, Chloride channel ABP protein, p64CLCP protein, NCC 27 protein, CLIC 1 protein, Regulatory nuclear chloride ion channel protein protein, RNCC protein., Chloride intracellular channel protein 1 hRNCC protein, G6 protein, CLIC1, CLIC-1 protein, Chloride intracellular channel 1 protein|
Coomassie Blue stained SDS-PAGE of CLIC1 protein (His tag) (80R-1332)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-241 amino acids: MGSSHHHHHH SSGLVPRGSH MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K|
|Purity||> 90% pure|
|Molecular Weight||29.0 kDa (261aa) , confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CLIC1 (Chloride intracellular channel 1), also referred to as NCC27, is a member of the highly conserved family of chloride ion channels that function in both soluble and integral membrane forms. This protein is a monomeric protein that contains a redox-active site similar to glutaredoxin; it functions as an anion-selective channel. It forms a dimer when oxidized and is then able to form chloride ion channels in bilayers and vesicles, whereas a reducing environment prevents this from occurring. Recombinant human CLIC1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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