CNDP2 protein (His tag) (80R-2619)
Purified recombinant Human CNDP2 protein (His tag)
|Synonyms||Cytosolic non-specific dipeptidase protein, HsT2298 protein, CNDP 2, CNDP 2 protein, CNDP-2, CN-2 protein, CPGL protein, CNDP2, CNDP-2 protein, CN 2 protein, CN2 protein, PEPA protein|
SDS-PAGE analysis of CNDP2 protein (His tag) (80R-2619)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-475 aa: MGSSHHHHHH SSGLVPRGSH MGSMAALTTL FKYIDENQDR YIKKLAKWVA IQSVSAWPEK RGEIRRMMEV AAADVKQLGG SVELVDIGKQ KLPDGSEIPL PPILLGRLGS DPQKKTVCIY GHLDVQPAAL EDGWDSEPFT LVERDGKLYG RGSTDDKGPV AGWINALEAY QKTGQEIPVN VRFCLEGMEE SGSEGLDELI FARKDTFFKD VDYVCISDNY WLGKKKPCIT YGLRGICYFF IEVECSNKDL HSGVYGGSVH EAMTDLILLM GSLVDKRGNI LIPGINEAVA AVTEEEHKLY DDIDFDIEEF AKDVGAQILL HSHKKDILMH RWRYPSLSLH GIEGAFSGSG AKTVIPRKVV GKFSIRLVPN MTPEVVGEQV TSYLTKKFAE LRSPNEFKVY MGHGGKPWVS DFSHPHYLAG RRAMKTVFGV EPDLTREGGS IPVTLTFQEA TGKNVMLLPV GSADDGAHSQ NEKLNRYNYI EGTKMLAAYL YEVSQLKD|
|Method of Purification||CNDP2 protein was purified using Protein G affinity chromatography|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Cytosolic non-specific dipeptidase, also known as CNDP2, is a cytosolic, non-specific dipeptidase that belongs to the peptidase M20A family of proteins. CNDP2 is a secreted peptidase homologous to M20 peptidases. It is expressed by all adult and fetal tissue, however, an isoform lacking exons 3 and 4 was expressed in all fetal tissue, but only in adult liver. Overexpression of CPGL-B in hepatocellular carcinoma cells leads to significant inhibition of HC cell viability, colony formation, cell invasiveness and tumor formation. Recombinant human CNDP2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
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