COL1A1 antibody (70R-14951)

Rabbit polyclonal COL1A1 antibody

Synonyms Polyclonal COL1A1 antibody, Anti-COL1A1 antibody, COL1 A1 antibody, COL1-A1 antibody, COL1A1, collagen type I alpha 1 antibody, OI4 antibody
Specificity human
Cross Reactivity human, mouse, rat and sheep. Based on the homology of the immunogen this antibody is expected to recognize the collagen I a1 polypeptide in all mammals, birds, and amphibians
Applications IHC, WB
Immunogen Peptide from the human collagen I a1 telopeptide sequence.

Images

Immunofluorescent staining using COL1A1 antibody (70R-14951)

Immunofluorescent staining of formaldehyde-fixed fibrotic mouse lung tissue. The antibody recognizes mature collagen I (red) that has formed fibrils in the extracellular matrix.

Specifications

Host Rabbit
Method of Purification COL1A1 antibody was purified by affinity chromatography
Molecular Weight 140 Kda
Form & Buffer Supplied in liquid form in PBS buffer

Usage & Assay Information

Usage Recommendations WB: 1:1000, IHC: 1:100

General Information

Biological Significance COL1A1 encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.

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Images

  • Immunofluorescent staining using COL1A1 antibody (70R-14951) | Immunofluorescent staining of formaldehyde-fixed fibrotic mouse lung tissue. The antibody recognizes mature collagen I (red) that has formed fibrils in the extracellular matrix.
  • Western Blot analysis using COL1A1 antibody (70R-14951) | Western blot of rat lung lysate showing specific immunolabeling of ~ 140 k collagen protein

Availability: In stock

Price: $335.00
Size: 100 ul
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