Complement C4 antibody (beta-chain) (10R-8470)

Mouse monoclonal Complement C4 antibody (beta-chain)

Synonyms Monoclonal Complement C4 antibody, Anti-Complement C4 antibody, C4A antibody, complement component 4A (Rodgers blood group) antibody, acidic C4 antibody, acidic complement C4 antibody, BOS_21584 antibody, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2 antibody, C4 antibody, C4-1 antibody, C4A2 antibody, C4A3 antibody, C4A4 antibody, C4A6 antibody, C4A anaphylatoxin antibody, C4AD antibody, C4b antibody, C4S antibody, co4 antibody, complement C4 antibody, complement C4-A antibody, complement component 4A antibody, complement component 4B (Chido blood group) antibody, complement component 4B (Childo blood group) antibody, complement component 4 antibody, gene 1 antibody, complement component 4 (within H-2S) antibody, cpamd2 antibody, DAMC-258G8.6 antibody, fourth component of complement antibody, RG antibody, Rodgers form of C4 antibody, sex-limited protein antibody, Slp antibody
Cross Reactivity Human
Applications ELISA, WB
Immunogen Complement C4 antibody was raised in Mouse using a protein purified from Human plasma as the immunogen

Images

Western Blot analysis using Complement C4 antibody (beta-chain) (10R-8470)

Specifications

Host Mouse
Clone 35A12
Isotype IgG1 kappa
Method of Purification Complement C4 antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance The complement system is a part of the larger immune system and three biochemical pathways are present: the classical complement pathway, the alternative pathway, and the mannose-binding lectin pathway. Complement component C4 is an essential component of humoral immune response. In its activated form, C4b becomes a subunit of the C3 convertase, which is an enzymatic complex that activates C3 of the classical and lectin complement activation pathways. The classical pathway is initiated by the activation of the C1-complex (C1q, C1r and C1s) by C1q's binding to antibody-antigen. The C1-complex now binds to and splits C2 and C4 producing C2a and C4b. C4b and C2a bind to form C3-convertase. Production of C3-convertase leads to cleavage of C3 into C3a and C3b and C3b joins with the C3 convertase to make C5 convertase.

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Images

  • Western Blot analysis using Complement C4 antibody (beta-chain) (10R-8470) |

Availability: In stock

Price: $295.00
Size: 100 ul
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