Complement C4 beta chain antibody (10R-8481)

Mouse monoclonal Complement C4 beta chain antibody

Synonyms Monoclonal Complement C4 beta chain antibody, Anti-Complement C4 beta chain antibody, C4B antibody, complement component 4B (Chido blood group) antibody, basic complement C4 antibody, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3 antibody, C4 antibody, C4-2 antibody, C4B1 antibody, C4B12 antibody, C4B2 antibody, C4B3 antibody, C4B5 antibody, C4BD antibody, C4F antibody, C4l antibody, CH antibody, Chido form of C4 antibody, CO4 antibody, complement C4-A-like antibody, complement C4-B antibody, complement C4B1a antibody, complement C4-like protein antibody, complement component 4B (Childo blood group) antibody, complement component 4 antibody, gene 2 antibody, complement component 4 (within H-2S) antibody, CPAMD3 antibody, DADB-112B14.11-001 antibody, Orla C4 antibody, PANDA_019918 antibody, Ss antibody
Cross Reactivity Human
Applications ELISA, IP, WB
Immunogen Complement C4 beta chain antibody was raised in Mouse using a protein purified from Human plasma as the immunogen

Images

Western Blot analysis using Complement C4 beta chain antibody (10R-8481)

Specifications

Host Mouse
Clone 52H10
Isotype IgG1 kappa
Method of Purification Complement C4 beta chain antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000, IP: 1 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Complement component C4 is an essential component of humoral immune response. In its activated form, C4b becomes a subunit of the C3 convertase, which is an enzymatic complex that activates C3 of the classical and lectin complement activation pathways. The classical pathway is initiated by the activation of the C1-complex (C1q, C1r and C1s) by C1q's binding to antibody-antigen. The C1-complex now binds to and splits C2 and C4 producing C2a and C4b. C4b and C2a bind to form C3-convertase. Production of C3-convertase leads to cleavage of C3 into C3a and C3b and C3b joins with the C3 convertase to make C5 convertase. Human C4 is the most polymorphic protein of the complement system. Complement C4 exists as two isotypes, C4A (acidic) and C4B (basic). Although the sequence identity is very high, they have different hemolytic activities, covalent affinities to antigens and immune complexes, and serological reactivities. Each C4 contains beta chain, alpha chain, C4a anaphyltoxin, C4b, and gamma chain.

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Images

  • Western Blot analysis using Complement C4 beta chain antibody (10R-8481) |

Availability: In stock

Price: $295.00
Size: 100 ul
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