Complement Factor C8 beta propeptide antibody (10R-8464)

Mouse monoclonal Complement Factor C8 beta propeptide antibody

Synonyms Monoclonal Complement Factor C8 beta propeptide antibody, Anti-Complement Factor C8 beta propeptide antibody, C8B antibody, complement component 8 antibody, beta polypeptide antibody, BOS_3527 antibody, complement component 8 antibody, beta subunit antibody, complement component 8 subunit beta antibody, complement component C8 beta chain antibody, complement component C8 beta subunit antibody, RP23-413I9.1 antibody
Cross Reactivity Human
Applications ELISA, IP, WB
Immunogen Complement Factor C8 beta propeptide antibody was raised in Mouse using a protein purified from Human plasma as the immunogen

Images

Western Blot analysis using Complement factor C8 beta propeptide antibody (10R-8464)

Specifications

Host Mouse
Clone 14A10
Isotype IgG1 kappa
Method of Purification Complement Factor C8 beta propeptide antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000, IP: 1 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance The complement system is a part of the larger immune system and three biochemical pathways are present: the classical complement pathway, the alternative pathway, and the mannose-binding lectin pathway. Human complement Factor C8 is one of five components (C5b, C6, C7, C8, and C9) that interact to form the cytolytic membrane attack complex (MAC) which is the cytolytic end product of the complement cascade. MAC is typically formed on the surface of intruding pathogenic bacterial as a result of the activation of the complement system, and it is one of the ultimate weapons of the immune system. C8 is composed of an alpha (64 kDa), beta (64 kDa), and gamma (22 kDa) subunit. Within C8, the subunits are arranged as a disulfide-linked C8 alpha-gamma heterodimer that is noncovalently associated with C8 beta. During MAC formation, C8 alpha mediates binding and self-polymerization of C9 to form a pore-like structure on the membrane of target cells.

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Images

  • Western Blot analysis using Complement factor C8 beta propeptide antibody (10R-8464) |

Availability: In stock

Price: $295.00
Size: 100 ul
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