Cortactin antibody (20R-2984)

Rabbit polyclonal Cortactin antibody

Synonyms Polyclonal Cortactin antibody, Anti-Cortactin antibody, CTTN antibody, cortactin antibody, amplaxin antibody, BOS_25081 antibody, cortactin isoform B antibody, CTTN1 antibody, Cttnb antibody, Ems1 antibody, ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate) antibody, mammary tumor and squamous cell carcinoma associated (p80/85 src substrate) antibody, oncogene EMS1 antibody, p80 antibody, p80/85 antibody, P85.25 antibody, src substrate cortactin antibody, src substrate protein p85 antibody
Cross Reactivity Human, Rat
Applications WB
Immunogen Cortactin antibody was raised in Rabbit using a synthetic target peptide as the immunogen

Images

Western Blot analysis using Cortactin antibody (20R-2984)

Specifications

Host Rabbit
Isotype IgG
Method of Purification Cortactin antibody was purified by Protein A affinity chromatography
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:5000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Cortactin is a ubiquitous actin-binding protein that was originally identified as a substrate for Src. It is accumulated in peripheral, actin-enriched structures of cells, including lamellipodia and membrane ruffles, suggesting that cortactin facilitates actin network formation. Cortactin has four major domains of interest:the N-terminal acidic (NTA) and tandem repeats domains, and the C-terminal proline-rich and SH3 Domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM by cancer cells. Cortactin is phosphorylated by src family kinases at Y421, Y466, and Y482 and S405 and S418 that are phosphorylated by Erk family kinases.

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Images

  • Western Blot analysis using Cortactin antibody (20R-2984) |

Availability: In stock

Price: $295.00
Size: 100 ul
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