COX2 antibody (10R-C144b)

Rabbit monoclonal COX2 antibody

Synonyms Monoclonal COX2 antibody, Anti-COX2 antibody, COX 2 antibody, COX2, COX 2, COX-2 antibody, Cycloxygenase 2 antibody, COX-2
Specificity Human
Cross Reactivity To be determined by end-user
Applications IHC-F, IHC-P
Immunogen COX2 antibody was raised in rabbit using a synthetic peptide from the c-terminus of rat COX 2 as the immunogen.

Images

Immunohistochemical staining using COX2 antibody (10R-C144b)

Specifications

Host Rabbit
Clone SP21
Isotype IgG
Molecular Weight 70 kDa (predicted detection band MW)
Form & Buffer Tissue culture supernatant with 0.09% NaN3.
Concentration Batch dependent - please inquire should you have specific requirements

Usage & Assay Information

Usage Recommendations IHC-F: 1:50-1:100, IHC-P: 1:50-1:100

Storage & Safety

Storage Store at 4 deg C.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

General Information

Biological Significance COX2 (Cyclooxygenase-2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters, and cytokines that induce its expression. Given its role in synthesizing prostaglandins, COX2 is therefore of interest in studying immune response regulation. COX2 is induced by a wide variety of stimuli and was initially identified as immediate-early growth response gene. In addition, COX2 expression markedly increased in 85-90% of human colorectal adenocarcinoma whereas COX1 levels remain unchanged.

References
Add a Paper

Jun Ma, Lynetta Phillips, Ying Wang, Tiane Dai, Janine LaPag, Rama Natarajan, Sharon G Adler

Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC

BMC Complementary and Alternative Medicine

Issue: 2010, 10:67 DOI: 10.1186/1472-6882-10-67

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Images

  • Immunohistochemical staining using COX2 antibody (10R-C144b) |

Availability: In stock

Price: $505.00
Size: 500 ul
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