CRLF2 protein (His tag) (80R-2726)
Purified recombinant CRLF2 protein (His tag)
|Synonyms||Cytokine receptor-like factor 2 isoform 1 precursor protein, CRL2 protein, CRLF2Y protein, TSLPR protein, CRLF2, CRLF 2, CRLF-2, CRLF 2 protein, CRLF-2 protein|
SDS-PAGE analysis of CRLF2 protein (His tag) (80R-2726)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||23-231 aa: MGSSHHHHHH SSGLVPRGSH MGSQGGAAEG VQIQIIYFNL ETVQVTWNAS KYSRTNLTFH YRFNGDEAYD QCTNYLLQEG HTSGCLLDAE QRDDILYFSI RNGTHPVFTA SRWMVYYLKP SSPKHVRFSW HQDAVTVTCS DLSYGDLLYE VQYRSPFDTE WQSKQENTCN VTIEGLDAEK CYSFWVRVKA MEDVYGPDTY PSDWSEVTCW QRGEIRDACA ETPTPPKPKL SK|
|Purity||> 85% pure|
|Molecular Weight||26.6 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol|
Storage & Safety
|Storage||Can be stored at 4 deg C for short terms (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles|
|Biological Significance||CRLF2 is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. Recombinant human CRLF2 protein, fused to His-tag at N-terminus, was expressed in E.coli.|
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