CSTB protein (His tag) (80R-1053)
Purified recombinant Human CSTB protein
|Synonyms||STFB., EPM1 protein, Cystatin B protein, CST6 protein, CSTB protein, PME protein, Liver thiol proteinase inhibitor protein, CystatinB CHROW21 protein, Stefin B protein, CPI B protein, CYTB protein|
Coomassie Blue stained SDS-PAGE of CSTB protein (His tag) (80R-1053)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-98 amino acids: MGSSHHHHHH SSGLVPRGSH MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF|
|Purity||> 95% pure|
|Molecular Weight||13 kDa (118aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0, containing 50mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Endotoxin Levels||< 1.0 EU per ug of protein (determined by LAL method)|
|Biological Significance||CSTB, also known as Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. This protein is able to form a dimer stabilized by noncovalent forces and is thought to play a role in protecting against the proteases leaking from lysosomes. In cells, CSTB is located in the lysosomes and the cytoplasm, but also in the nucleus. Recombinant CSTB, fused to His-tag, was expressed in E. coli and purified by using conventional chromatography techniques.|
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