CTDSP2 antibody (10R-1344)

Mouse monoclonal CTDSP2 antibody

Synonyms Monoclonal CTDSP2 antibody, Anti-CTDSP2 antibody, CTDSP 2, CTDSP 2 antibody, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 antibody, SCP2 antibody, OS4 antibody, CTDSP-2 antibody, PSR2 antibody, CTDSP-2, CTDSP2
Specificity Human CTDSP2
Cross Reactivity Human. Other species not studied
Applications Dot Blot
Immunogen CTDSP2 antibody was raised in mouse using recombinant Human Ctd (Carboxy-Terminal Domain, Rna Polymerase Ii, Polypeptide A) Small Phosphatase 2 (Ctdsp2)

Images

Western Blot analysis of immunized recombinant protein using CTDSP2 antibody (10R-1344)

Specifications

Host Mouse
Clone 2230C1a
Isotype IgG2b
Method of Purification CTDSP2 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer CTDSP2 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance CTDSP2 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas

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Images

  • Western Blot analysis of immunized recombinant protein using CTDSP2 antibody (10R-1344)

Availability: In stock

Price: $190.00
Size: 50 ug
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