CTLA4 antibody (70R-14931)

Affintiy purified rabbit polyclonal CTLA4 antibody

Synonyms CTLA4 antibody, CTLA 4 antibody, CTLA-4 antibody, Cytotoxic T-lymphocyte protein 4 antibody, CD152 antibody, N terminal CTLA4 antibody, CD152
Specificity N-terminal CTLA4 (CD152)
Applications ELISA, IHC, WB
Immunogen CTLA4 antibody (N terminal) was raised in Rabbit using a KLH conjugated synthetic peptide between 57-86 amino acids from the N-terminal region of human IDDM12 as the immunogen

Images

Western Blot analysis using CTLA4 antibody (N terminal) (70R-14931)

Western blot analysis using CTLA4 antibody (N terminal)in WiDr cell lysates (35ug/lane).This demonstrates the CTLA4 antibody detected the CTLA4 protein (arrow)

Specifications

Host Rabbit
Isotype IgG
Method of Purification CTLA4 antibody was purified through a protein A column, followed by peptide affinity purification
Form & Buffer Liquid in PBS with 0.09% (W/V) sodium azide
Concentration 0.5 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:1000, IHC: 1:1:50-100, WB: 1:100-500

Storage & Safety

Storage Store at 2-8 deg C for short periods. For longer periods of storage, store at -20 deg C. Avoid repeat freeze-thaw cycles.

General Information

Biological Significance CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.

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Images

  • Western Blot analysis using CTLA4 antibody (N terminal) (70R-14931) | Western blot analysis using CTLA4 antibody (N terminal)in WiDr cell lysates (35ug/lane).This demonstrates the CTLA4 antibody detected the CTLA4 protein (arrow)
  • Immunohistochemical staining using CTLA4 antibody (N terminal) (70R-14931) | Immunohistochemical staining in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.

Availability: In stock

Price: $495.00
Size: 400 ul
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