CTLA4 protein (His tag) (80R-2663)
Purified recombinant Human CTLA4 protein (His tag)
|Synonyms||CTLA-4, CTLA-4 protein, CTLA 4, GSE protein, GRD4 protein, CELIAC3 protein, CTLA4, ICOS protein, IDDM12 protein, CD152 protein, Cytotoxic T-lymphocyte protein 4 isoform CTLA4-TM precursor protein, CTLA 4 protein|
SDS-PAGE analysis of CTLA4 protein (His tag) (80R-2663)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||36-161 aa: MGSSHHHHHH SSGLVPRGSH MGSKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSI CTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSD|
|Method of Purification||CTLA4 protein was purified using Protein G affinity chromatography|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CTLA4 is a member of the immunoglobulin superfamily and transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. Recombinant human CTLA4 protein, fused to His-tag at N-terminus, was expressed in E.coli.|
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