cTnI antibody (10R-1833)

Mouse monoclonal cTnI antibody

Synonyms Monoclonal cTnI antibody, Anti-cTnI antibody, TNNC1 antibody, MGC116817 antibody, CMH7 antibody
Cross Reactivity Human
Applications ELISA, IHC, WB
Immunogen cTnI antibody was raised in Mouse using a purified recombinant fragment of cTnI expressed in E. coli as the immunogen.

Images

Immunohistochemical staining using cTnI antibody (10R-1833)

Immunohistochemical analysis of paraffin-embedded human normal cardiac muscle tissue, showing cytoplasmic localization using cTnI antibody with DAB staining.

Specifications

Host Mouse
Clone 3A10A12,5C3A7
Isotype IgG1
Form & Buffer Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration 1.0 mg/ml

Usage & Assay Information

Usage Recommendations ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance cTnI along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. TNNI3 is the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues.

References
Add a Paper

Liliana Sfichi-Dukea, Mary L. Garcia-Cazarina, C. Amelia Sumandeaa, Gail A. Sieverta, C. William Balkea, Dong-Yun Zhanb, Sachio Morimotob, Marius P. Sumandea

Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins

Journal of Molecular and Cellular Cardiology

Volume: 48 Issue: 5 Page: 934-942 DOI: 10.1016/j.yjmcc.2010.01.005

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Images

  • Immunohistochemical staining using cTnI antibody (10R-1833) | Immunohistochemical analysis of paraffin-embedded human normal cardiac muscle tissue, showing cytoplasmic localization using cTnI antibody with DAB staining.
  • Western Blot analysis using cTnI antibody (10R-1833) | Western Blot showing cTnI antibody used against truncated cTnI recombinant protein.

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Price: $295.00
Size: 100 ul
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