CUL2 antibody (70R-10479)

Affinity purified rabbit polyclonal CUL2 antibody

Synonyms Polyclonal CUL2 antibody, Anti-CUL2 antibody, cullin 2 antibody, CUL 2 antibody, CUL 2, CUL-2 antibody, MGC131970 antibody, CUL-2, CUL2
Cross Reactivity Human, Mouse, Rat, Dog, Bovine, African Clawed Frog
Applications WB
Immunogen CUL2 antibody was raised in rabbit using the middle region of CUL2 as the immunogen
Assay Information CUL2 Blocking Peptide, catalog no. 33R-3799, is also available for use as a blocking control in assays to test for specificity of this CUL2 antibody

Images

Western blot analysis using CUL2 antibody (70R-10479)

Recommended CUL2 Antibody Titration: 0.2-1 ug/ml

Specifications

Host Rabbit
Form & Buffer Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-1 ug/ml

Storage & Safety

Storage Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.

General Information

Biological Significance CUL2 is a core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. This protein may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

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Images

  • Western blot analysis using CUL2 antibody (70R-10479) | Recommended CUL2 Antibody Titration: 0.2-1 ug/ml

Availability: In stock

Price: $345.00
Size: 50 ug
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