Cyclin E antibody (20R-CR032)

Rabbit polyclonal Cyclin E antibody

Synonyms Polyclonal Cyclin E antibody, Anti-Cyclin E antibody, CCNE antibody, Cyclin Es antibody, G1/S specific cyclin E antibody, CyclinE antibody, CCNE1 antibody, Cyclin E1 antibody, Cyclin Et antibody
Specificity Human
Cross Reactivity Mouse
Applications IF, IP, Kinase Assay, WB
Immunogen Cyclin E antibody was raised in rabbit using a synthetic peptide derived from the c-terminus of human cyclin E as the immunogen.

Specifications

Host Rabbit
Method of Purification Cyclin E antibody was purified by Protein A chromatography.
Molecular Weight 50 kDa (predicted detection band MW)
Form & Buffer Protein A purified IgG supplied in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3.
Concentration ~1.0 mg/ml

Usage & Assay Information

Usage Recommendations WB: 5-10 ug/ml

Storage & Safety

Storage Store at 4 deg C.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

General Information

Biological Significance Cyclin E is a regulatory subunit of cdk-2 and controls G1/S transition during the mammalian cell cycle. Multiple isoforms of cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post-transcriptional regulation of cyclin E. In vitro analyses indicated that these truncated variant isoforms of cyclin E are able to phosphorylate histone H1. Alterations in cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

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Availability: In stock

Price: $410.00
Size: 500 ug
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