Cytochrome C antibody (10R-8465)

Mouse monoclonal Cytochrome C antibody

Synonyms Monoclonal Cytochrome C antibody, Anti-Cytochrome C antibody, CYCS antibody, cytochrome c antibody, somatic antibody, BOS_4320 antibody, CYC antibody, CYCSA antibody, cyct antibody, cytc antibody, cytochrome c antibody, Cytochrome C antibody, expressed in somatic tissues antibody, cytochrome c antibody, testis antibody, cytochrome c antibody, testis-specific antibody, EGK_13845 antibody, hcs antibody, somatic cytochrome c antibody, TEgg084a23.1 antibody, THC4 antibody
Cross Reactivity Human, Mouse, Rat
Applications WB
Immunogen Cytochrome C antibody was raised in Mouse using a His-tagged recombinant human Cytochrome C protein purified from E.coli as the immunogen

Images

Western Blot analysis using Cytochrome C antibody (10R-8465)

Specifications

Host Mouse
Clone 14G6
Isotype IgG1 kappa
Method of Purification Cytochrome C antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1: 2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Cytochrome c is a small heme protein consisting electron-transport chain in mitochondria and transfers electrons between complex III and IV. It is highly conserved through diverse species from unicellular microorganisms to animals and plants. Cytochrome c is also an intermediate in apoptosis. Currently, it is widely accepted that mitochondria play a key role in the regulation of apoptosis. In mammalian cells, a major caspase activation pathway is the cytochrome c-initiated pathway. In this pathway, a variety of apoptotic stimuli cause cytochrome c release from mitochondria. In the cytosol, cytochrome c interacts with its adaptor molecule, Apaf-1, resulting in the recruitment, processing and activation of pro-caspase-9 in the presence of dATP or ATP. Caspase-9, in turn, cleaves and activates pro-caspase-3 and -7; these effector caspases are responsible for the cleavage of various proteins leading to biochemical and morphological features characteristic of apoptosis.

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Images

  • Western Blot analysis using Cytochrome C antibody (10R-8465) |

Availability: In stock

Price: $295.00
Size: 100 ul
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