DCX antibody (10R-8358)

Mouse monoclonal DCX antibody

Synonyms Monoclonal DCX antibody, Anti-DCX antibody, Doublecortex Lissencephaly X-Linked antibody, Doublecortin antibody, DBCN antibody, DC antibody, LISX antibody, SCLH antibody, XLIS antibody
Applications IHC, WB

Images

Immunofluorescent staining using DCX antibody (10R-8358)

Immunofluorescent staining of cultured rat neurons showing strong cytoplasmic staining of doublecortin (green) in developing neurons and GFAP in red

Specifications

Host Mouse
Clone 3 e1
Isotype IgG2A
Method of Purification DCX antibody was purified by affinity chromatography
Form & Buffer Supplied in liquid form in PBS buffer + 10 mM NaN3

Usage & Assay Information

Usage Recommendations WB: 1:5000, IF: 1:1000

General Information

Biological Significance In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The protein contains two doublecortin domains, which bind microtubules. In addition, DCX interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex.

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Images

  • Immunofluorescent staining using DCX antibody (10R-8358) | Immunofluorescent staining of cultured rat neurons showing strong cytoplasmic staining of doublecortin (green) in developing neurons and GFAP in red
  • Western Blot analysis using DCX antibody (10R-8358) | Western blot of postnatal day 3 rat brain lysate showing specific immunolabeling of ~35 & 45kdoublecortin protein

Availability: In stock

Price: $335.00
Size: 100 ul
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