DCXR protein (His tag) (80R-1381)
Purified recombinant Human DCXR protein
|Synonyms||L-xylulose reductase protein, kiDCR protein, HCRII protein, Dicarbonyl/L-xylulose reductase protein, XR protein, DCR protein, P34H protein, Kidney dicarbonyl reductase protein, HCR2 protein, Sperm surface protein P34H protein, Carbonyl reductase II protein, , KIDCR protein|
Coomassie Blue stained SDS-PAGE of DCXR protein (His tag) (80R-1381)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-244 amino acids: MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC|
|Purity||> 95% pure|
|Molecular Weight||28 kDa (264aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 1mM DTT, 20% glycerol and 50mM NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Dicarbonyl/L-xylulose reductase, also known as DCXR, is an enzyme responsible for the metabolism of xylulose, converting it into xylitol. DCXR was expressed at low levels and was localized predominantly in the cytoplasmic membrane. In contrast, in virtually all grades of early-stage prostate cancer and in all chemohormonally treated cases, DCXR was strikingly overexpressed and was localized predominantly in the cytoplasm and nucleus. Recombinant human DCXR, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques|
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