DDR1 antibody (10R-1994)
Mouse monoclonal DDR1 antibody
|Synonyms||Monoclonal DDR1 antibody, Anti-DDR1 antibody, mammarian carcinoma kinase 10 antibody, epithelial discoidin domain receptor 1 antibody, neuroepithelium antibody, discoidin domain receptor 1 antibody, nep antibody, CAK antibody, DDR1, EDDR1 antibody, MCK10 antibody, cell adhesion kinase antibody, DDR 1, DDR-1, Drd1 antibody, DDR-1 antibody, DDR 1 antibody|
|Immunogen||DDR1 antibody was raised in Mouse using a purified recombinant fragment of DDR1(aa602-681) expressed in E. coli as the immunogen.|
Western Blot analysis using DDR1 antibody (10R-1994)
Western Blot showing DDR1 antibody used against truncated MBP-DDR1 recombinant protein (1).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||DDR1 is a Receptor Tyrosine Kinase that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.|
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