DEDD protein (His tag) (80R-2649)

Purified recombinant Human DEDD protein (His tag)

Synonyms DEFT protein, FLDED1 protein, CASP8IP1 protein, DEDD1 protein, KE05 protein, Death effector domain-containing protein protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

SDS-PAGE analysis of DEDD protein (His tag) (80R-2649)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 1-318 aa: MGSSHHHHHH SSGLVPRGSH MAGLKRRASQ VWPEEHGEQE HGLYSLHRMF DIVGTHLTHR DVRVLSFLFV DVIDDHERGL IRNGRDFLLA LERQGRCDES NFRQVLQLLR IITRHDLLPY VTLKRRRAVC PDLVDKYLEE TSIRYVTPRA LSDPEPRPPQ PSKTVPPHYP VVCCPTSGPQ MCSKRPARGR ATLGSQRKRR KSVTPDPKEK QTCDIRLRVR AEYCQHETAL QGNVFSNKQD PLERQFERFN QANTILKSRD LGSIICDIKF SELTYLDAFW RDYINGSLLE ALKGVFITDS LKQAVGHEAI KLLVNVDEED YELGRQKLLR NLMLQALP
Expression System E.coli
Method of Purification DEDD protein was purified using Protein G affinity chromatography
Tag/Conjugate His tag
Form & Buffer Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
Concentration 500 ug/ml

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Death effector domain-containing protein, also known as DEDD, is a cytoplasmic protein. It translocates to the nucleus during CD95-mediated apoptosis, where it localizes to nucleoli-like structures, activates caspase-6 and specifically inhibits RNA polymerase I-dependent transcription. The cell death activity of DEDD relates to its nuclear localization. DEDD is widely expressed in a variety of tissues, with highest levels in the testis. Overexpression of this gene was shown to induce weak apoptosis. Recombinant human DEDD protein, fused to His-tag at N-terminus, was expressed in E.coli.

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Images

  • <div><font face=Calibri size=2>SDS-PAGE analysis of DEDD protein (His tag) (80R-2649)</font></div>     | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: $365.00
Size: 50 ug
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