Diablo antibody (20R-2899)

Rabbit polyclonal Diablo antibody

Synonyms Polyclonal Diablo antibody, Anti-Diablo antibody, DIABLO antibody, diablo antibody, IAP-binding mitochondrial protein antibody, BOS_16495 antibody, DBO antibody, DFNA64 antibody, diablo homolog antibody, diablo homolog (Drosophila) antibody, diablo homolog antibody, mitochondrial antibody, DIABLO-S antibody, direct IAP binding protein with low PI antibody, Direct IAP-binding protein with low pI antibody, hCG_1782202 antibody, mitochondrial diablo antibody, mitochondrial diablo-like protein antibody, mitochondrial Smac protein antibody, Second mitochondria-derived activator of caspase antibody, second mitochondrial derived activator of caspases antibody, Smac antibody, smac3 antibody, XSmac antibody
Cross Reactivity Human
Applications IHC-P, WB
Immunogen Diablo antibody was raised in Rabbit using a synthetic target peptide as the immunogen

Images

Western Blot analysis using Diablo antibody (20R-2899)

Specifications

Host Rabbit
Isotype IgG
Method of Purification Diablo antibody was purified by Protein A affinity chromatography
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:1000-2000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance The mitochondrial protein Smac/DIABLO (second mitochondria-derived activator) performs a critical function in apoptosis by eliminating the inhibitory effect of IAPs (inhibitor of apoptosis proteins) on caspases. The newly synthesized Smac protein contains 239 amino acids. Its N-terminal 55 residues encode the mitochondrial-targeting sequence and are proteolytically removed in the mature Smac protein. In the intrinsic cell death pathway, the key event leading to the activation of caspases is the release of several pro-apoptotic proteins such as Smac/DIABLO from the intermembrane space of mitochondria into the cytosol. During apoptosis, Smac is released from mitochondria and re-activates the processed initiator and effector caspases by relieving IAP-mediated inhibition. Furthermore, Smac/DIABLO plays an important regulatory role in the sensitization of cancer cells to both immune-and drug-induced apoptosis.

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Images

  • Western Blot analysis using Diablo antibody (20R-2899) |

Availability: In stock

Price: $295.00
Size: 100 ul
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