DJ1 antibody (20R-2972)

Rabbit polyclonal DJ1 antibody

Synonyms Polyclonal DJ1 antibody, Anti-DJ1 antibody, PARK7 antibody, parkinson protein 7 antibody, BOS_15809 antibody, CAP1 antibody, contraception-associated protein 1 antibody, CTA-215D11.1 antibody, Dj1 antibody, DJ-1 antibody, DJ-1 protein antibody, fertility protein SP22 antibody, oncogene DJ1 antibody, park7a antibody, Parkinson disease 7 antibody, Parkinson disease (autosomal recessive antibody, early onset) 7 antibody, Parkinson disease (autosomal recessive antibody, early onset) 7 a antibody, parkinson disease protein 7 homolog antibody, protein DJ-1 antibody, protein DJ-1-like antibody, putative Parkinson disease autosomal recessive early onset 7 variant 1 antibody, RNA-binding protein regulatory subunit antibody, RP23-272N19.5 antibody, SP22 antibody, TEgg028p24.1 antibody, zDJ-1 antibody
Cross Reactivity Human, Mouse, Rat
Applications WB
Immunogen DJ1 antibody was raised in Rabbit using a recombinant human protein purified from E.coli (HIS-DJ-1) as the immunogen

Images

Western Blot analysis using DJ1 antibody (20R-2972)

Specifications

Host Rabbit
Isotype IgG
Method of Purification DJ1 antibody was purified by affinity chromatography
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000-5000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Parkinson?s disease (PD) is the second most common neurodegenerative disorder after Alzheimer?s disease, with a prevalence of 1?2% in population aged 65 years or older. PD is a complex, multifactorial disorder that typically manifests after the age of 50 years. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. alpha-synuclein and parkin are thought to be firmly associated with PD. The exact biological function of the DJ-1 protein is currently unknown. It may play a role in the oxidative stress response, and this function could be important in preventing the onset of PD. Defects in PARK7 are the cause of autosomal recessive early-onset Parkinson disease 7 (PARK7). The human DJ-1 protein contains 189 amino acid residues. DJ-1 may possess an active site and could also be a protease/hydrolase similar to the PfpI proteases. The DJ-1 gene has been highly conserved in evolution. The structures of the mouse and human DJ-1 genes are similar, and human and mouse DJ-1 proteins display 90% amino acid identity.

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Images

  • Western Blot analysis using DJ1 antibody (20R-2972) |

Availability: In stock

Price: $295.00
Size: 100 ul
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