DKK1 protein (His tag) (80R-2775)

Purified recombinant DKK1 protein (His tag)

Synonyms Dickkopf-related protein 1 protein, DKK-1 protein, SK protein, DKK1, DKK 1, DKK-1
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

SDS-PAGE analysis of DKK1 protein (His tag) (80R-2775)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 32-266 aa: MGSSHHHHHH SSGLVPRGSH MGSTLNSVLN SNAIKNLPPP LGGAAGHPGS AVSAAPGILY PGGNKYQTID NYQPYPCAED EECGTDEYCA SPTRGGDAGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC VSSDQNHFRG EIEETITESF GNDHSTLDGY SRRTTLSSKM YHTKGQEGSV CLRSSDCASG LCCARHFWSK ICKPVLKEGQ VCTKHRRKGS HGLEIFQRCY CGEGLSCRIQ KDHHQASNSS RLHTCQRH
Expression System E.coli
Purity > 90% pure
Molecular Weight 28.2 kDa
Tag/Conjugate His tag
Form & Buffer Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Concentration 1 mg/ml

Storage & Safety

Storage Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.

General Information

Biological Significance Dickkopf-related protein 1, also known as DKK1, antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Recombinant human DKK1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

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Images

  • SDS-PAGE analysis of DKK1 protein (His tag) (80R-2775) | Figure annotation denotes ug of protein loaded and % gel used.
  • SDS-PAGE analysis of DKK1 protein (His tag) (80R-2775) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: $270.00
Size: 100 ug
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