DMTF1 antibody (10R-1205)

Mouse monoclonal DMTF1 antibody

Synonyms Monoclonal DMTF1 antibody, Anti-DMTF1 antibody, Cyclin D binding myb-like transcription factor 1 antibody, DMTF1, DMP1 antibody, DMTF 1 antibody, DMTF-1, DMTF antibody, DMTF 1, DMTF-1 antibody, hDMP1 antibody
Specificity Human DMTF1
Cross Reactivity Human. Other species not studied
Applications Dot Blot
Immunogen DMTF1 antibody was raised in mouse using recombinant Cyclin D Binding Myb-Like Transcription Factor 1

Images

Western Blot analysis of immunized recombinant protein using DMTF1 antibody (10R-1205)

Specifications

Host Mouse
Clone DMTF5I250
Isotype IgG1
Method of Purification DMTF1 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer DMTF1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

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Images

  • Western Blot analysis of immunized recombinant protein using DMTF1 antibody (10R-1205)

Availability: In stock

Price: $190.00
Size: 50 ug
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