DNAJC15 protein (His tag) (80R-3006)
Purified recombinant DNAJC15 protein (His tag)
|Synonyms||DnaJ homolog subfamily C member 15 protein, DNAJD1 protein, HSD18 protein, MCJ protein, DNAJC 15 protein, DNAJC-15 protein|
SDS-PAGE analysis of DNAJC15 protein (His tag) (80R-3006)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||58-150 aa: MGSSHHHHHH SSGLVPRGSH MGSFRIWKPL EQVITETAKK ISTPSFSSYY KGGFEQKMSR REAGLILGVS PSAGKAKIRT AHRRVMILNH PDKGGSPYVA AKINEAKDLL ETTTKH|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% glycerol, 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage, for long term storage aliquot and store at -20 deg C or -70 deg C, avoid repeated freeze thaw cycles.|
|Biological Significance||ASCC1 is a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in ASCC1 are associated with Barrett esophagus and esophageal adenocarcinoma.|
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