DOK1 antibody (70R-10511)
Affinity purified rabbit polyclonal DOK1 antibody
|Synonyms||Polyclonal DOK1 antibody, Anti-DOK1 antibody, MGC117395 antibody, P62DOK antibody, MGC138860 antibody, 62kDa, DOK 1 antibody, DOK 1, DOK-1, docking protein 1, DOK1, DOK-1 antibody, downstream of tyrosine kinase 1 antibody|
|Immunogen||DOK1 antibody was raised in rabbit using the C terminal of DOK1 as the immunogen|
Western Blot analysis using DOK1 antibody (70R-10511)
DOK1 antibody (70R-10511) used at 0.2-1 ug/ml to detect target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.|
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