DYNLL1 protein (His tag) (80R-1506)
Purified recombinant Human DYNLL1 protein
|Synonyms||DNCL1 protein, DYNLL-1 protein, DYNLL 1 protein, DLC8 protein, LC8 protein, hdlc1 protein, LC8a protein, DYNLL1, DLC1 protein, DYNLL 1, DNCLC1 protein, MGC126138 protein, MGC126137 protein, Dynein light chain 1 cytoplasmic protein, PIN, DYNLL-1|
Coomassie Blue stained SDS-PAGE of DYNLL1 protein (His tag) (80R-1506)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-89 amino acids: MGSSHHHHHH SSGLVPRGSH MCDRKAVIKN ADMSEEMQQD SVECATQALE KYNIEKDIAA HIKKEFDKKY NPTWHCIVGR NFGSYVTHET KHFIYFYLGQ VAILLFKSG|
|Purity||> 90% pure|
|Molecular Weight||12.5 kDa (109aa) confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 0.2M NaCl, 1mM DTT and 10% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||DYNLL1, also known as DLC8 or PIN (protein inhibitor of neuronal nitric oxide synthase), has been identified as a protein that interacts with NOS1 resulting in NOS1 inhibition. Binding of this protein destabilizes NOS1(Neuronal nitric oxide synthase) dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. DYNLL1 is a ubiquitously expressed protein that exhibits high expression in testis and moderate expression in brain. Recombinant human DYNLL1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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