Dysbindin protein (His tag) (80R-1122)
Purified recombinant Human Dysbindin protein
|Synonyms||Dystrobrevin-binding protein 1 isoform C Dystrobrevin binding protein 1 protein, Hermansky Pudlak syndrome 7 protein., DBND protein, HPS7 protein, SDY protein, DTNBP1 protein|
Coomassie Blue stained SDS-PAGE of Dysbindin protein (His tag) (80R-1122)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-270 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMLS AHWEKKKTSL VELQEQLQQL PALIADLESM TANLTHLEAS FEEVENNLLH LEDLCGQCEL ERCKHMQSQQ LENYKKNKRK ELETFKAELD AEHAQKVLEM EHTQQMKLKE RQKFFEEAFQ QDMEQYLSTG YLQIAERREP IGSMSSMEVN VDMLEQMDLM DISDQEALDV FLNSGGEENT VLSPALGPES STCQNEITLQ VPNPSELRAK PPSSSSTCTD SATRDISEGG ESPVVQSDEE EVQVDTALAT SHTDREATPD GGEDSDS|
|Purity||> 95% pure|
|Molecular Weight||34.6 kDa (307aa), confirmed by MALDI-TOF.|
|Form & Buffer||20mM Tris-HCl buffer, pH 8.0, containing 100mM NaCl, 0.5mM DTT, and 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Dysbindin is a ubiquitously expressed protein that binds to alpha- and beta-dystrobrevins, components of the dystrophin-associated protein complex (DPC) in both muscle and nonmuscle cells. Dysbindin has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies. Among its known functions, dysbindin is part of a protein complex, termed the biogenesis of lysosome-related organelles complex 1 (BLOC-1), the molecular components of which might be involved in the regulation of vesicular trafficking and dendrite branching. Dysbindin effects for brain volume and cortical thickness appear driven by different neurobiological processes. Recombinant human Dysbindin protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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