EIF2AK3 antibody (10R-2262)
Mouse monoclonal EIF2AK3 antibody
|Synonyms||Monoclonal EIF2AK3 antibody, Anti-EIF2AK3 antibody, Eukaryotic translation initiation factor 2-alpha kinase 3 antibody, EIFAK3-2, WRS antibody, EIFAK3 2 antibody, EIFAK3-2 antibody, Pancreatic eIF2-alpha kinase antibody, PERK antibody, EIF2AK3, EIFAK3 2|
|Immunogen||EIF2AK3 antibody was raised in Mouse using a purified recombinant fragment of human EIF2AK3 expressed in E. coli as the immunogen.|
Western Blot analysis using EIF2AK3 antibody (10R-2262)
Western Blot showing EIF2AK3 antibody used against HEK293 (1) and EIF2AK3 (AA: 929-1116)-hIgGFc transfected HEK293 (2) cell lysate.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||EIF2AK3 phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.|
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