EIF2B1 protein (His tag) (80R-1781)
Purified recombinant Human EIF2B1 protein
|Synonyms||EIF2BA protein, 26kD protein, EIFB1 2 protein, EIF2B1, MGC117409 protein, MGC125868 protein, EIFB1-2 protein, MGC125869 protein, EIF-2B protein, Eukaryotic translation initiation factor 2B protein, EIF2B protein, EIFB1-2, EIF-2Balpha protein, subunit 1 alpha protein, EIFB1 2|
Coomassie Blue stained SDS-PAGE of EIF2B1 protein (His tag) (80R-1781)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-305 amino acids: MGSSHHHHHH SSGLVPRGSH MDDKELIEYF KSQMKEDPDM ASAVAAIRTL LEFLKRDKGE TIQGLRANLT SAIETLCGVD SSVAVSSGGE LFLRFISLAS LEYSDYSKCK KIMIERGELF LRRISLSRNK IADLCHTFIK DGATILTHAY SRVVLRVLEA AVAAKKRFSV YVTESQPDLS GKKMAKALCH LNVPVTVVLD AAVGYIMEKA DLVIVGAEGV VENGGIINKI GTNQMAVCAK AQNKPFYVVA ESFKFVRLFP LNQQDVPDKF KYKADTLKVA QTGQDLKEEH PWVDYTAPSL ITLLFTDLGV LTPSAVSDEL IKLYL|
|Purity||> 90% pure|
|Molecular Weight||35.8 kDa(325aa) confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||EIF2B1 is one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Phosphorylation of eIF2 inhibits GEF activity of EIF2B, an inhibition that requires the eIF2B1 subunit. Defects in eIF2B1 are a cause of leukoencephalopathy with vanishing white matter (VWM), a brain disease that is characterized by head trauma and motor deterioration. Recombinant human EIF2B1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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